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Reduce glycemic variability and HbA1c levels
using continuous glucose monitoring vs. fingersticks alone
The revolutionary Guardian
®
RT system gives patients the benefits of continuous glucose
monitoring in REAL-Time, around the clock. Continuous glucose monitoring is proven to improve
patient outcomes versus fingersticks alone by reducing glycemic variability and HbA1c levels.
2
-5
More meaningful insights than fingersticks alone
P
atient response to REAL-Time alarms resulted in a
48% r
e
ductio
n in m
ean duration of hypoglycemic
excursion, from 64.4 minutes to 33.6 minutes
(P = 0.004).
5
Patients in the control group, without
R
EAL-Tim
e alarms, experienced no significant change
Reduces HbA1cs and related complications
• Reduces long-term diabetes complications: Continuous glucose monitoring has been shown to help guide
therapy adjustment leading to reductions in HbA1c levels versus the use of fingersticks alone
2
-4
— Each 1% reduction in HbA1c reduces the risk of long-term complications like eye, nerve, kidney and heart
disease by 15% to 30%
7
,12
Fingersticks taken 4 times only
give you part of the picture
*
Lows missed bythese fingersticks
Highs missed by these fingersticks
Continuous glucose monitoring
3:00 AM
0
5.6
11.1
16.7
6:00 AM 9:00 AM 12:00 PM 3:00 PM 6:00 PM 9:00 PM
Time of day
3:00 AM 6:00 AM 9:00 AM 12:00 PM 3:00 PM 6:00 PM 9:00 PM
Time of day
Fingersticks alone
Glucose - mmol/L
0
5.6
11.1
16.7
Glucose - mmol/L
Target zone
Target zone
Continuous glucose monitoring
completes the picture
Lows missed bythese fingersticks
Highs missed by these fingersticks
Continuous glucose monitoring
3:00 AM
0
5.6
11.1
16.7
6:00 AM 9:00 AM 12:00 PM 3:00 PM 6:00 PM 9:00 PM
Time of day
3:00 AM 6:00 AM 9:00 AM 12:00 PM 3:00 PM 6:00 PM 9:00 PM
Time of day
Fingersticks alone
Glucose - mmol/L
0
5.6
11.1
16.7
Glucose - mmol/L
Target zone
Target zone
REAL-Time alarms helped reduce the
duration of hypoglycemic excursions
10
P = 0.03
By helping to reduce HbA1c levels, continuous
gluc
ose mo
nit
or
in
g helps to reduce the risk of long-
term complications and increase a patient’s lifespan
7
Continuous glucose monitoring
reduces HbA1cs
9.0
8.5
8.0
7.5
7.0
P = n.s. P = .011
6.5
6.0
Start 6 weeks
Continuous glucose monitoring vs. fingersticks
4
HbA1c, % ± SE
12 weeks
Fingersticks alone
CGM
Better detects hypoglycemia and hyperglycemia
for more proactive patient self-management
• Identifies hidden variability: Continuous glucose monitoring helps
r
e
veal dangerous glucose variability that may not be tracked by
fingersticks alone and HbA1c testing
6
— 60% of lows may not be revealed when using fingersticks alone.
9,11
HbA1c testing provides a 2 to 3 month average of glucose levels
and isn’t intended to track highs and lows
6
— Continuous glucose monitoring identifies up to 4 times more
glucose excursions requiring therapy adjustment versus
fin
g
ers
tick
s alo
n
e, so patients can intervene more quickly
3
* Chart is illustrative of a patient taking 4 fingersticks in one day, at times shown.
•
Measures glucose levels continuously:
Jus
t as the systems of a human
body monitors glucose levels to guide insulin release, continuous
glucose monitoring measures glucose 24 hours a day giving patients
meaningful insights to help guide therapy decisions
• HbA1c testing and fingersticks alone provide less meaningful insights
because they do not monitor glucose levels continuously
— HbA1c testing is performed at a single point in time, once every
2 to 3 months and produces an average blood glucose level
— Fingersticks also measure glucose levels at a single point in time —
patients test on average 4 to 5 times per day
• REAL-Time continuous glucose monitoring provides updated glucose
readings every five minutes — up to 288 glucose measurements per
day — to alert patients to take action sooner
2-5